Circular RNAs (circRNA) are a growing class of non-coding RNAs. Their stable circulation in plasma and possible link with cancer makes them attractive for biomarker studies. Several pipelines and methods for circRNA discovery have been published but large-scale validation of the predicted circRNAs is lacking. My research is focused on in vitro validation of predicted circRNAs with a particular interest in circRNAs deregulated in cancer. Using this information and circRNA predictions on large-scale RNA sequencing datasets of thousands of cancer patients, cancer cell lines and healthy individuals; I will then build the most comprehensive cancer circRNA resource.