OncoRNALab

The lab of Prof. Jo Vandesompele and Prof. Pieter Mestdagh at Ghent University

The OncoRNALab is supervised by Prof. Jo Vandesompele and Prof. Pieter Mestdagh at Ghent University, Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences. It is part of the Center for Medical Genetics and the Cancer Research Institute Ghent.
The lab’s research aims to exploit RNA for diagnostic and therapeutic purposes. The various research lines converge on studying the role of non-coding RNA in cancer and on the utility of extracellular RNA in liquid biopsies. Through a combination of high-throughput (functional) genomics technologies and bio-informatics tools, we seek to answer various fundamental and translational research questions.

News

Hear what Dr. Wim Trypsteen has to say on Nio+

Learn what Europe’s leading digital PCR knowledge center, the dPCR consortium at the University of Ghent, had to say about their experience with Nio™+.

Wim Trypsteen

Last updated on Nov 22, 2023 1 min read

Welcome Scott!

We welcome Scott Ailliet to to the OncoRNALab team!

Scott Ailliet

Oct 17, 2023 1 min read

OncoRNALab Colleagues Shine at ACTC Conference 2023 with liquid biopsy RNA research

OncoRNALab researchers received acclaim and explored promising collaborative opportunities at the 6th edition of the Advances in Cirtulating Tumor Cells (ACTC) conference, all against the breathtaking backdrop of the Greek island.

Anneleen Decock, Annelien Morlion

Last updated on Sep 27, 2023 2 min read

OncoRNALab Colleagues Shine at ACTC Conference 2023 with liquid biopsy RNA research

Congratulations to Dr. Deleu

Lab member Jill obtained her PhD degree

Jill Deleu, Bram De Wilde, Tom Van Maerken, Jo Vandesompele

Sep 18, 2023 1 min read

Welcome Thijs!

We welcome Thijs Van der Snickt to to the OncoRNALab team!

Thijs Van der Snickt

Sep 1, 2023 1 min read

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Projects

circRNA

circular RNAs in cancer

exRNAQC

controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

CiLiQuant

tool to determine the relative circular and linear abundance of transcripts

CIRCprimerXL

tool for primer design for circRNAs

digital PCR

digital PCR data-analysis tools developed by the Ghent University Digital PCR Consortium

EV-TRACK

crowdsourcing knowledgebase with experimental parameters of public extracellular vesicles (EV) studies

LNCASO

antisense oligonucleotide design for long non-coding RNAs

LNCipedia

a comprehensive compendium of human long non-coding RNAs

miRBase Tracker

easy-to-use online database that keeps track of all historical and current miRNA annotation present in the miRBase database

miSTAR

microRNA target prediction

primerXL

state-of-the-art PCR assay design for quantitative and digital PCR, targeted resequencing, double-mismatch allele specific PCR (DMAS), and 4C

RDML database

public database for sharing of quantitative and digital PCR using the RDML data exchange format

ZipperPlot

visualization and analysis method to evaluate human transcription start sites in relation to publicly available CAGE-sequencing, ChIP-sequencing and DNase-sequencing datasets