OncoRNALab

The lab of Prof. Jo Vandesompele and Prof. Pieter Mestdagh at Ghent University

The OncoRNALab is supervised by Prof. Jo Vandesompele and Prof. Pieter Mestdagh at Ghent University, Department of Biomolecular Medicine, Faculty of Medicine and Health Sciences. It is part of the Center for Medical Genetics and the Cancer Research Institute Ghent.
The lab’s research aims to exploit RNA for diagnostic and therapeutic purposes. The various research lines converge on studying the role of non-coding RNA in cancer and on the utility of extracellular RNA in liquid biopsies. Through a combination of high-throughput (functional) genomics technologies and bio-informatics tools, we seek to answer various fundamental and translational research questions.

News

The journey of spatial transcriptomics

Unlocking the mysteries of tumor tissue architecture

Congratulations to Dr. Morlion

Lab member Annelien obtained her PhD degree

A doctorate as a flight

Doctoral fellow Annelien writes a blog for Eos Magazine

Projects

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circRNA

circular RNAs in cancer

exRNAQC

controlling pre-analytical variables of RNA sequencing in blood-based precision medicine

CiLiQuant

tool to determine the relative circular and linear abundance of transcripts

CIRCprimerXL

tool for primer design for circRNAs

digital PCR

digital PCR data-analysis tools developed by the Ghent University Digital PCR Consortium

EV-TRACK

crowdsourcing knowledgebase with experimental parameters of public extracellular vesicles (EV) studies

LNCASO

antisense oligonucleotide design for long non-coding RNAs

LNCipedia

a comprehensive compendium of human long non-coding RNAs

miRBase Tracker

easy-to-use online database that keeps track of all historical and current miRNA annotation present in the miRBase database

miSTAR

microRNA target prediction

primerXL

state-of-the-art PCR assay design for quantitative and digital PCR, targeted resequencing, double-mismatch allele specific PCR (DMAS), and 4C

RDML database

public database for sharing of quantitative and digital PCR using the RDML data exchange format

ZipperPlot

visualization and analysis method to evaluate human transcription start sites in relation to publicly available CAGE-sequencing, ChIP-sequencing and DNase-sequencing datasets

The Lab

Principal Investigators

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Jo Vandesompele

Professor

Non-coding RNA, Extracellular RNA, Liquid biopsies, Pan-cancer, Method development

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Pieter Mestdagh

Professor

Non-coding RNA, Cancer, Extracellular RNA, Liquid biopsies, Bioinformatics, Immune oncology

PostDoctoral Fellows

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Anneleen Decock

PostDoctoral Fellow

Cancer, Extracellular RNA, Liquid biopsies, Pediatric tumors, Cancer diagnostics, detection and prognosis

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Annelien Morlion

PostDoctoral Fellow

Bioinformatics, Liquid biopsies, RNA, Cancer

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Bram De Wilde

PostDoctoral Fellow

Cancer, Non-coding RNA

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Eric J. de Bony

PostDoctoral Fellow

Non-coding RNA, Cancer, Bioinformatics

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Jill Deleu

PostDoctoral Fellow

Cancer, Extracellular RNA, Liquid biopsies, Pediatric tumors

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Kathleen Schoofs

PostDoctoral Fellow

Cancer, Non-coding RNA

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Louis Delhaye

PostDoctoral Fellow

Cancer, Non-coding RNA, RNA-protein interactions, Antisense technology, Neuroblastoma

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Tom Van Maerken

PostDoctoral Fellow

Cancer, Non-coding RNA

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Wim Trypsteen

PostDoctoral Fellow

Cancer, Non-coding RNA

Doctoral Fellows

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Elena Ramos Varas

Doctoral Fellow

Bioinformatics, RNA, Cancer

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Franco Poma Soto

Doctoral Fellow

Spatial -omics, Single-cell sequencing, Cancer

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Hanne Van Droogenbroeck

Doctoral Fellow

Cancer, Non-coding RNA, Extracellular RNA, Liquid biopsies, Pediatric tumors, Spatial transcriptomics

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Philippe Decruyenaere

Doctoral Fellow

Lymphoma, exRNA, Non-coding RNA, Liquid Biopsies

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